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About the Study
The E4Comfort Study is evaluating an oral study medication to see if it may reduce hot flashes and night sweats in post-menopausal women. Estetrol, the study medication, is a synthetic form of the naturally occurring estrogen. It has shown in early testing to have minimal side effects.  

How Can You Qualify?
You may be able to participate if you:
  • Are a post-menopausal woman aged 40-65 years
  • Experience moderate-to-severe hot flashes or night sweats
  • Started menopause within the last 10 years
  • Do not have a history of cancer, diabetes, or heart disease
  • Still have your uterus (have not had a hysterectomy)

Additional requirements will apply. The study staff can provide more details.
Participation in this study is completely voluntary and you may withdraw from the study at any time.

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If you suffer from Hot Flashes OR Night Sweats, please consider joining our study.

Estetrol is a synthetic form of the naturally occurring estrogen produced by fetal liver during pregnancy. It reaches maternal circulation via the placenta. It has shown in early testing to have minimal side effects. 

Please contact us below for more information or to get started:

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